Recently, evolution of novel nanomaterials with specified properties has attracted considerable attention as potent candidates for the drug delivery at the tissue and cellular levels, and proficient loading of pharmaceutical agents for the treatment of cancer. Zinc oxide (ZnO) based nanomaterials are found to be toxic to cancer cells  and can be designed in various shapes (e.g. ZnO tetrapods) and forms (Zinc per oxide, ZnO2). This work will use different zinc oxide forms in drug delivery to breast cancer cells. Microchannels are designed within PDMS (Polydimethylsiloxane) matrix by etching of ZnO tetrapods. These PDMS sponges are tested for delivering the Cisplatin to breast cancer cells through these channels. On the other hand, ZnO2 in combination with drug (Cisplatin or paclitaxel) will be investigated for their toxicity on the breast cancer, and also normal, healthy cells.