Magnetic particle mapping using magnetoelectric sensors as an imaging modalityTuesday (18.06.2019) 20:17 - 20:18
Magnetic nanoparticles have been investigated extensively for diagnostics and therapy in medical life science. Elaborate but also very expensive methods such as magnetic resonance imaging (MRI), magnetic particle imaging (MPI), and magnetorelaxometry imaging (MRX) were developed. Here we propose a novel technique, magnetic particle mapping (MPM), that uses resonant magnetoelectric sensors for the detection of magnetic nanoparticles. A simple and straightforward procedure for setup and measurement enables the detection of higher harmonic excitations of magnetic nanoparticle ensembles. We demonstrate the feasibility of such an approach by building a measurement system particularly suited to exploit the sensor’s inherent properties. We measure the magnetic response from 2D magnetic nanoparticle distributions and reconstruct the distribution by solving the inverse problem. Furthermore, biological samples with magnetically labeled cells were measured and reconstructions of the cell distributions were compared with the original distribution. The results suggest that our method is very promising technique for magnetic nanoparticle imaging in life science and other fields.