Controlled Design and in Vitro Anticancer Study of Highly Biocompatible, Biodegradable and Stimuli-Responsive Porous Superparamagnetic Sub Micron Vaterite Particles for Thermo-ChemotherapyTuesday (18.06.2019) 20:19 - 20:20
Porous inorganic nanoparticles are gaining widespread attention as a universal nanoscale delivery system due to their unique properties. Calcium carbonate (CaCO3) has been considered as a prospective material for smart drug delivery application due to its low cost, biodegradability, high drug loading capacity, excellent biocompatibility, and pH-sensitive decomposition. The inability to control the size and morphology of the CaCO3 particle and loading a payload into the common synthesis method is the main hurdle associated with the preparation. Here we report the synthesis of a highly porous, spherical superparamagnetic vaterite particles (PMVP) of size ~ 800nm for anticancer treatment. Amongst the CaCO3 polymorphs, vaterite is an ideal candidate for the controlled drug delivery application due to its large porosity, surface area and swift decomposition under mild conditions. PMVP were synthesized in a one-step reaction by encapsulating the Iron oxide nanoparticles (IONPs) and the DOX molecules in the PMVP through electrostatic attraction and physisorption. The main advantage of the PMVP DOX is that it can be magnetically targeted into the tumor region and once exposed to the tumor tissues characteristic acidic pH, the PMVP nanoparticle dissociates, releasing the DOX and intelligently converts the pH-triggered drug release into a tumor triggered drug release. Simultaneous application of alternating magnetic field results in the temperature rise of the tumor tissues due to the hyperthermic capability of the IONPs in the PMVP and results in the synergistic tumoricidal activities.